Newsletter – Autumn 2023

Welcome to the Autumn edition of our newsletter! The aim of this newsletter is to keep you informed on upcoming events and opportunities, as well as to share with you the achievements of our students.

If you have any news items you wish to be included in future newsletters, please email them to a member of the comms team!

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News

  • Welcome to our new cohort of 2023 starters! We are so excited for you to be a part of the White Rose DTP, and look forward to seeing all that you accomplish.
  • Symposium 2023

Registration for our Annual Symposium is now open! Attendance is compulsory for all students, except for those on placements. Any student on their PIPS or in their 5th year on extension is welcome to attend the symposium, however this is not mandatory.

This year the Symposium will take place at the Cloth Hall Court, Leeds on Friday 8th December, 09:00 – 18:00. 

  • 4th Year students must submit an abstract using this form (deadline Monday 30th October) for either a research or PIPS talk.
  • 3rd year students will need to make a poster based on their research. Poster criteria and submission deadlines will be communicated nearer the time.
WRDTP 2022 Symposium at the University of York

To have a look at what the day will be like, check out our archived symposium highlights from previous years!

  • DTP Residential 2023

Our 2023 residential will be held from the 6th to the 9th of November at YHA Langdale in the Lake District. It will be a great opportunity to get to know people both from other year groups, and from the other universities, in an informal setting, and will include a mix of fun, social time, cohort building, and training sessions. It is recommended for 1st and 2nd year students, and optional for years 3 and 4.

The registration deadline has been extended to the 6th of October. 

Things you may have missed…

There are many things going on behind the scenes that may have flown under the radar!

  • DTP Science Book Spotlight blogs

Are you passionate about reading? Look no further! Isobel from our Comms team has started a book review blog series in which you will be treated to regular reviews on popular science books. Her first post discusses ‘The Immortal Life of Henrietta Lacks’ by Rachel Skloot, the controversial story behind the cultured HeLa cells and the black US-American woman to whom those cells belong.

If you are interested in writing your own review, or even just have some science book recommendations, then please get in touch with a member of the comms team!

  • Where has your PhD taken you?

Back in January, we sent around a questionnaire about where you have travelled to as part of your PhD. In case you missed our Tweet, here are some highlights from the responses we received!

Have you been somewhere that isn’t on these maps! Help us keep them up to date by letting us know!

  • A note from your comms team  

Are you interested in science communication and/or are wanting to fill that CV? We’re looking for new members to join the WRDTP comms team! No experience required and time commitment can be flexible. Whether it is writing one-off blog posts (like our book reviews) or becoming a permanent member of the team, it would be great to welcome some new faces and perspectives onto the team! If you are interested or would like more information, please contact a member of the team.

Student Achievements

This is where we usually mention students who have given talks, won awards and published papers. However, due to technical issues based around Twitter/X, we’ve been unable to keep up with all of your amazing achievements this time! If you (or someone you know) have any achievements you think we should know about, then please get in touch!

Careers Spotlight: Alex Holmes, Teaching Fellow at the University of Leeds

Meet Alex: Alex started her PhD at the University of Leeds in 2018 and finished with her viva in December of 2022. We have asked Alex all about her career, as well as any advice that she has for current students considering a career in academia.

Read moreCareers Spotlight: Alex Holmes, Teaching Fellow at the University of Leeds

Adam Parker – Enza Zaden

For his PIPS, Adam went to Enza Zaden in the Netherlands. Enza is an international vegetable breeding company and seed supplier.

The featured image is of tulip/hyacinth fields in spring

Adam in the greenhouse with his lettuce

What did you do?

At the company, I worked in the Phytopathology team, which is involved in all aspects related to plant immunity. They develop tools for diagnosis, and detection of crop diseases, as well as identifying resistance genes that can be used in breeding programmes. During my time, I worked primarily with lettuce, where I tested certain lines for their tolerance to drought and disease resistance to Downy mildew (Bremia lactucae).

What made you want to do that particular placement?

My PhD project is mostly fundamental science. I wanted an opportunity that demonstrated how similar work can be used for agriculture. Enza as a company invests a large sum of money into research as they appreciate the value this has in the development of new crop varieties. I also wanted to go somewhere abroad as I think being exposed to new work environments and cultures has benefits both in personal development and career outlook. Therefore, Enza Zaden was a perfect match for me.

The company grounds

How did you go about finding and planning your PIPS?

Enza has previously worked with Uni of Sheffield and therefore my PhD supervisor was able to give me a contact in the phytopathology team. I reached out to them and asked if they would be willing to host me for 3 months. I was lucky enough that they said yes! I tried to plan my PIPS to land at the start of my 3rd year just after Christmas. For me, it was the best time to do it as it gave a nice midway break to the PhD.

Friday drinks at the docks

What have you gained from doing your PIPS?

Working at a company gave me an insight into life outside of academia. While I am still not set on my career path, I was delighted to have enjoyed it so much. I would certainly consider and/or seek out a career in industry. Aside from the technical skills of working at a breeding company, I think I gained the most in terms of personal development. I was thrown into an unfamiliar situation in an unfamiliar country, which forced me to find my feet and socialise with new people. I think this has boosted my ability to form professional contacts and friends in a relatively short period of time. I have also come back to Sheffield with a fresh perspective on work/life balance. 

The view from Adam’s desk

How would you sum up your PIPS experience?

Excellent! I don’t think it could have worked out much better. I was in a friendly department in a company that matched my interests. I had accommodation and a small stipend which made moving out there super easy. Furthermore, the town had multiple large breeding companies which meant there was a welcoming and lively international community of similarly aged people. 

What advice would you give to other PGRs about PIPS?

It’s critical to plan the timing of your PIPS placement well. Not necessarily in terms of a certain year of your PhD, but in a way that doesn’t disrupt your PhD work. I had a natural transition between experiments at the start of my third year, so I decided to do my PIPS then. This meant I could wrap up one aspect of my work before leaving, ready to start a new aspect when I came back. In doing so, I was not stressed and/or working on my PhD while I was away, which allowed me to make the most of the 3-month placement.

Megan Clarke – The Royal Society

The Royal Society logo

For Megan‘s PIPS, she joined the Science Policy department at The Royal Society, working with the Living Landscapes team on the upcoming ‘Multifunctional Landscapes’ policy Report which explores the evidence for how the land can be utilised to deliver multiple outputs.

The featured image is of The Royal Society logo.

What did you do?

I was tasked with gathering evidence, writing sections of the report, making figures, editing, and proof reading.

The Multifunctional Landscapes Report is due to be published in November 2022 and I attended meetings to discuss launch plans with expert Steering Group members. The Living Landscapes team were keen to invite ministers to the launch event so I also wrote and sent invites to the Secretaries of State from Defra (George Eustice) and DLUHC (Michael Gove, at the time).

Megan volunteering at the Summer Science Exhibition

Using the evidence outlined in the Report, I also prepared a response to a House of Lords inquiry on Land Use in England on behalf of The Royal Society. This gave me the opportunity to write for a policy audience and improved my communication skills in this area.

My time at The Royal Society coincided with their annual Summer Science Exhibition which is the Society’s flagship public engagement event. Throughout the week, I volunteered as a Let’s Talk Careers Session Facilitator which provided A-Level students with an insight into a wide variety of research careers within science. 

What made you want to do this particular placement?

I wanted to gain an insight into potential career options in science communication and science policy and the UKRI Policy Internship gave me the opportunity to do this. I chose The Royal Society as it is the UK’s National Academy of Science and has a strong influence on government policymaking. I felt that a placement here would allow me to work on some of the most pressing policy issues.  

How did you go about finding and planning your PIPS?

I applied to the UKRI Science Policy internship scheme online. This involved answering questions about why I had chosen my particular host partner, and why I wanted to do the internship. I also had to write a 2-page POST Note style policy briefing on an issue of my choice. 

After submitting my application, I was contacted by my chosen host partners and invited to interviews via Teams. When I was offered a place, I was put in touch with my future line manager at The Royal Society to discuss the logistics of my internship.  

What have you gained from doing your PIPS?

I have gained a lot of valuable skills that I will bring back to my PhD and that I can use in my future career. I am more confident in my own abilities and know that if I wanted a career in science policy in the future, I would be well-equipped to succeed in one.

How would you sum up your PIPS experience?

I really enjoyed my time at The Royal Society and learnt a lot about science policy, which was an area I previously knew very little about. I appreciated my time away from the lab and valued the opportunity to gain insight into careers outside of academia.

What advice would you give to other PGRs about PIPS?

Don’t worry if you’re not too sure what you want to do after your PhD – and don’t let that influence where you apply to do your PIPS. Anywhere you go will provide you with great transferrable skills and give you an awareness of what careers are on offer outside of academia. Even if, at the end, you don’t see yourself working in the field you chose for your PIPS, at least you’ve learned that!

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If you are interested in applying to the UKRI policy internship scheme, you can find more details here!

CABI

The logo for CABI

CABI (Centre for Agriculture and Biosciences International) is an international not-for-profit organization that improves people’s lives by providing information and applying scientific expertise to solve problems in agriculture and the environment. We bring science-based agricultural knowledge to millions of smallholder farmers helping to increase their yields and adopt data-driven approaches to support informed decision making.

Read moreCABI

OZBRIUM – Cambridge

The logo for the Obrizum group

OBRIZUM Group was established in 2015 to transform digital learning. We are a Cambridge-based EdTech company at the forefront of the AI-led eLearning revolution. Our founders discovered that the amount of information we need to consume and apply is increasing exponentially. However, existing eLearning methodologies — which present information linearly — cannot scale with this rapidly increasing body of global knowledge, and will eventually collapse.

Read moreOZBRIUM – Cambridge

Cloud-SPAN – Deadlines 13th & 31st March 2023

Cloud-SPAN is a collaboration between the University of York and The Software Sustainability Institute funded by the UKRI innovation scholars award. It aims to train researchers to effectively generate and analyse a range of ‘omics data using Cloud computing resources.

We have 2 upcoming Cloud-SPAN courses. Both of the courses are free of charge and we offer scholarships to support costs associated with attending the course:

Read moreCloud-SPAN – Deadlines 13th & 31st March 2023

SysMIC – Course starting 24th April 2023

An image advertising the SysMIC on-line training for bioscientists, coding modelling analysis

SysMIC is an online course developed in association with the BBSRC to provide effective training for the bioscience community. It involves approximately 120 hours of study over six months and has a flexible format designed to fit around research commitments. It is suitable both for PhD students requiring initial training or established researchers looking to enhance and develop their skills portfolio. The course was put together jointly by academics from UCL, Birkbeck, the Open University and University of Edinburgh and since 2012 over 3,000 researchers have
tudied with us

Watch a brief overview of SysMIC here

Find out more at: https://sysmic.ac.uk

You can get a discount on the course fees for signing up as a DTP student.  (You can use your RTSG for this, in consultation with your supervisor).  If you wish to sign up for the SysMIC course, please contact the DTP Co-ordinator, email: WRDTP@leeds.ac.uk.  The course is run twice a year so there will be other opportunities if the timing is not right for you at this stage.

2023 BBSRC Bursaries for Birmingham Metabolomics Training Centre – Deadline 3rd May

Dates: 15th – 18th of May 2023
Location: School of Biosciences, the University of Birmingham

Do you want to attend this course for FREE?

There are a limited number of bursaries available for LC-MS Based Metabolomics and Metabolite Identification with the Q Exactive Plus and Orbitrap ID-X Tribrid. These bursaries cover the registration cost of BBSRC-funded researchers, making it completely free for them to attend. Further guidance, eligibility criteria, terms and conditions can be found on the application form below. Please apply promptly to avoid disappointment.

Read more2023 BBSRC Bursaries for Birmingham Metabolomics Training Centre – Deadline 3rd May

Newsletter – Spring 2023

BBSRC WRDTP Newsletter Autumn 2022

Happy New Year! Welcome to the first 2023 edition of the WRDTP Newsletter, a regular email which will go out at the start of each semester! The aim of this newsletter is to keep you informed on upcoming events and opportunities, as well as to share with you the achievements of our students.

If you have any news items you wish to be included in future newsletters, please email them to a member of the Comms Team!

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News

DTP Symposium, Dec 12th 2022

A huge thank you to everyone who took part in our December symposium! Whether you helped to organise the event, gave a talk about your research or PIPS placement, brought along a poster or even just attended, you helped to make the event a roaring success.

Congratulations to those who won prizes on the day! Jess Davis won first place for her research talk, followed by Theo Issitt and Laura Cowell. Our first place poster prize went to Victoria Hill, second to Lydia Barber and third to Aidan Johnson. Joanna Greenman won first place for her flash talk, followed by Jessica Edge and Liam Barratt, and Roz Latham won best PIPS talk.

We also heard from some excellent Keynote speakers: Dr Richard Malham (Head of Research Policy, Integrity and Governance, University of St Andrews) and Dr Rupert Lewis (Chief Science Policy Officer at the Royal Society), and our Q&A panel allowed for interesting discussions about life after finishing a PhD. Thank you to Dr Sarah Harvey (Mewburn Ellis LLP), Dr Claire Stoker (Spirit Medical Communications Group Limited) and Dr Elspeth Ransom (Defra) for forming our panel this year!

Spring Training Day, 29th March 2023, York

The first event of our new training programme is the Spring Training Day, which will be held in York on the 29th of March. The Spring Training Day aims to bring together the whole cohort: with years 1-2 having analytics training and years 3-4 training hopefully focusing on essential skills such as public speaking, publishing, job hunting and interviews/viva. There will also be time for social activities and cohort building! Make sure you have completed this form by the 20th of January. This is a compulsory part of the DTP training schedule so please make every effort to attend!

A note from your comms team  

Are you interested in science communication and/or are wanting to fill that CV? We’re looking for new members to join the WRDTP Comms Team! No experience required and time commitment can be flexible. Whether it is writing one-off blog posts or becoming a permanent member of the team, it would be great to welcome some new faces and perspectives onto the team! If you are interested or would like more information, please contact a member of the Comms Team.

Student Achievements 

Prizes and awards

Congratulations to: Patrick Hunter, who won 3rd place for research and career showcase poster prize; Theo Issit for winning a £9000 Elsie may Sykes award for a pilot study in cancer patients at York hospital, being a 3-minute thesis national finalist and Falling walls Delft winner; and Gemma Banister for a successful grant application for a 3-month placement under the UK-Canada Globalink Doctoral Exchange Scheme with UKRI.

Publications

Below is a list of recent publications from some of our students: 

We understand that there are many more achievements worth celebrating that are not mentioned above, and we apologise to anybody not included! To avoid this in the future, it would be great if you could let us know what you have been up to, either via email or by tagging the WRDTP account (@BBSRCWhiteRose) on twitter.

Newsletter – Autumn 2022

BBSRC WRDTP Newsletter Autumn 2022

Welcome to the first edition of the WRDTP Newsletter, a regular news update which will be released at the start of each semester! The aim of this newsletter is to keep you informed on upcoming events and opportunities, as well as to share with you the achievements of our students.

If you have any news items you wish to be included in future newsletters, please email them to a member of the Comms team!

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News

Welcome to our new cohort of 2022 starters! We are so excited for you to be a part of the White Rose DTP, and look forward to seeing all that you accomplish.

Masterclasses 2022

DTP masterclasses were a brand new, exciting concept launched in 2021. Our 2022 masterclasses hosted at Leeds, York and Sheffield were a great way for students to delve into the latest developments in an area of research with top academics from each university. 

This year, talks were focussed in the areas of: Navigating the academic environment, genome engineering, super-resolution imaging, analysis of microbial omics data, single-cell RNAseq, and cryo electron microscopy. We hope that most students were able to attend at least one of the masterclasses that was relevant to their research, and that you were also able to get to know your DTP colleagues from across all years and universities!

We are looking forward to running our masterclasses again in 2023, and would love some suggestions as to which topic areas you wish to be covered! It would be great to cover the areas that you will find the most interesting and useful in order for everyone to get the most out of these sessions.

“Learning about how to work with raw RNAseq data in our Masterclass on microbial omics” – @GavinHThomas on Twitter

DTP Symposium, Dec 12th 2022 

Registration for our annual symposium is now open! Attendance is compulsory for all students, except for those on placements. Unlike the past two years, this year’s event will be held entirely in person! This means that no posters or talks will be accessible virtually and we encourage everyone to attend.

This year, the symposium will take place at The University of York on Monday 12th December, 09:00 – 18:00. 

  • 4th Year students must submit an abstract (deadline Monday 31st October)
  • 3rd year students will need to make a poster based on their research. Poster criteria and submission deadlines will be communicated nearer the time.

A note from your comms team

Are you interested in science communication and/or are wanting to fill that CV? We’re looking for new members to join the WRDTP comms team! No experience required and time commitment can be flexible. Whether it is writing one-off blog posts or becoming a permanent member of the team, it would be great to welcome some new faces and perspectives onto the team! If you are interested or would like more information, please contact a member of the comms team!

Student Achievements (Easter-Summer 2022)

Prizes 

Congratulations to Ezra Herman, a student in the Friman lab from York who has been awarded the Enrichment Placement Award from the The Alan Turing Institute! 

A huge well done also to Alex Holmes who won the Leeds Partnership Awards 2022

Publications

Below is a list of recent publications from some of our students: 

Other achievements

See what else our students have been up to!

  • University of York students Harry Pink and Ethan Redmond both presented their research at the ICAR conference in Belfast. Read about their experience here!
  • Leeds student Alex Holmes hosted a gameshow at Be Curious 2022. See here to read more! 

We understand that there are many more achievements worth celebrating that are not mentioned above, and we apologise to anybody not included! To avoid this in the future, it would be great if you could let us know what you have been up to, either via email or by tagging the WRDTP account (@BBSRCWhiteRose) on twitter.

Jess Davis – Roundabout

For her PIPS, Jess chose to do something slightly different. She volunteered for Roundabout: South Yorkshire’s biggest youth homelessness charity which supports over 300 16-25 year olds every day. Roundabout provide a range of support from emergency accommodation, to bespoke career advice and tenancy support.

The featured image is of the roundabout logo

What did you do?

I worked for a charity called Roundabout, which is South Yorkshire’s biggest youth homelessness charity, supporting over 300 16-25 year olds, every day. They provide a range of support from emergency accommodation, to bespoke career advice and tenancy support. Because Roundabout is a relatively small, local, charity I got the opportunity to work across multiple different departments, and therefore got a great feeling of the charity overall, and how charities are managed and operate.

Two days a week I worked in ‘Central services’. This is the administrative and financial side of the charity. Here I helped with housing benefit applications, balancing books and working out why some client accounts were in arrears. I also helped in the maintenance of the client database, and learnt about the legislation surrounding trustees.  

Once a week I worked at ‘Homeless prevention services’. This is a drop in service in Sheffield city centre, where young people who are homeless, or need housing advice can come, and get free, unbiased support. The best part about this service is that no young person is ever turned away, the Roundabout staff always find a safe place for them to stay. Here, I shadowed and learnt how to interview young people who presented at the service and learnt about the different streams of support available to homeless young people, either from the council or local charities. I also helped in writing their 2021 National Lottery Annual Report, and the final Children in Need report for Roundabout’s five-year funding cycle. I interpreted data collected by the drop in service and made graphs to best display the charities output and contribution towards preventing youth homelessness in South Yorkshire.  

Twice a week I worked at the Roundabout hostel. Here I improved some of their documentation for recording client information, making it more stream lined and user friendly. I also spent a lot of time getting to know the young people, and supported them in day-to-day tasks. I also independently ran ‘life skill’ sessions where I baked and cooked with the residents, and organised their Christmas party.

Cooking for the Roundabout hostel Christmas party

In addition to this, I also did some work with the fundraising team. I assisted in the organisation and running of multiple events including the ‘South Yorkshire chocolate festival’, which was attended by 2000 people, a ‘Sleep out’ event, and I also ran a stall at the Sheffield Christmas market educating the public about youth homelessness and the work of Roundabout. Finally, I also got the opportunity to work with the Grants team. I successfully wrote an application to a community grant sponsored by Vodaphone, which was awarded. I also researched and wrote a letter to City Fibre enquiring about obtaining free Wi-Fi for all residents, and applied to a community grant with the South Yorkshire Community Foundation (SYCF), both of which we are yet to hear the outcome of. 

Jess running the Roundbout ‘Sleep Out’ stall at the Sheffield Christmas market

 What made you want to do that particular placement?

I wanted to take this PIPS opportunity to experience something outside of science, and to hopefully make a positive impact on my local community. I also wanted to gain experience and skills that are more easily recognised by companies outside of science and academia, for example in finance, management and teamwork.  

How did you go about finding and planning your PIPS?  

I had already heard of the amazing work being done by Roundabout in South Yorkshire, so I sent them a message on the ‘Contact us’ portion of their website, describing who I am, the skills I have, and explaining what a PIPS placement entails.

I wasn’t expecting to hear back from them, but they emailed me back almost straight away! I then arranged to meet with them in person and discuss what I could potentially do during my internship. Before this meeting I had made a fresh CV and made a list of things I would like to do during the placement, which really helped steer the meeting and plan what I could be involved in. I then started 2 months later and had the best time!

What have you gained from doing your PIPS?

The biggest thing that I gained from my PIPS was confidence in my abilities. Working in an environment where there were no expectations put on me meant that I really thrived. I have learnt that it’s always best to just give something a go even if you’re not 100 % sure on what you’re doing, it’s better to just try than to not do anything at all!

I gained more confidence in my ability to back myself and confidently put forward ideas. Working with a wide range of people at Roundabout has made me realise that as PhD students we have strong problem-solving skills and often come up with good ideas. It was really nice to be surrounded by other positive, enthusiastic members of staff. I also learnt so much about business and people management. Being an intern and working in so many different teams meant that I saw a lot of different working and management styles. I learnt so much about the general organisation of the charity, the hiring process, and how everyone’s roles fit into the overall running of Roundabout. Very interesting! 

How would you sum up your PIPS experience?

My PIPS has been an amazing time and has made me realise that as PhD students we have a lot more skills than we think we do! I think I have grown a lot as a person. I am so grateful to my PIPS supervisor Geoff for taking me on, and to everyone at Roundabout for making it such a lovely time. Every day was so varied and I genuinely looked forward to going in every day!

What advice would you give to other PGRs about PIPS?

PIPS seem like a really daunting and stressful thing to organise, but in truth they are not, I promise! If you are interested in working in the charity sector I would definitely recommend reaching out to a smaller, local charity rather than a ‘big name’ charity (i.e. CRUK, the NSPCC, Age UK etc). Smaller charities have less infrastructure and are therefore more flexible and more likely to be able to take on a PIPS. Additionally, because they generally don’t take on PhD interns you can really shape what you spend your time doing and you are special because you are the first/only one!

Robert Brench – ADAS

Robert is a 3rd-year PhD student at the University of Sheffield who completed his PIPS placement at ADAS, the UK’s largest independent provider of agricultural and environmental consultancy, policy advice and research and development. He was able to connect to ADAS with the help of LinkedIn, which has proven to be a vital networking tool. The WRDTP has its own LinkedIn group and page for our students to join and follow which we hope will enable more connections such as Robert’s in the future.

The featured image is of the logo for ADAS.

What did you do?

I worked with crop physiology and agronomy consultants at ADAS.

My first task was to review existing methods of analysing data gathered on farms and similar data sets and examine different methods to analyse the data collected over the last 7 years. I delivered the results of this as a presentation to the crop physiology group within ADAS.

The next part of my placement involved working with various consultants with trial carried out with various industrial partners using new products and techniques. This largely involved data preparation and analysis.

What made you want to do that particular placement?

I have long had an interest in the agricultural sector understanding how it works, the improvements that can be made and the changes necessary to move towards a more sustainable future. As a group who work closely with UK growers and the larger companies that support these growers, ADAS was centrally placed to provide insight into these interests.

How did you go about finding and planning your PIPS?

I reached out to a previous researcher at the university of Sheffield via LinkedIn and they helped me to arrange a placement.

What have you gained from doing your PIPS?

I have gained a larger appreciation of agricultural consulting. The skills that are required and the expertise and knowledge necessary. I have a greater appreciation for a range of statistical tools required in this field, some of which are transferable to my PhD work.

Secondly, the requirement to work to strict deadlines with multiple projects running in tandem has allowed the development of my organisation and time keeping skills. As well as a greater appreciation of my own abilities keeping to deadlines and the importance of reasonable expectations, particularly workload.

Finally, I have developed a network of contacts within an industry I am interested in working in after my PhD.

How would you sum up your PIPS experience?

Overall, my PIPS placement was a very positive experience, allowing me to work in an engaging environment and providing me with first-hand experience in an industry that greatly interests me. Not only will the skills I have been able to develop, but the contacts I have made, will undoubtedly provide new potential opportunities after finishing my PhD.

What advice would you give to other PGRs about PIPS?

I would strongly suggest investing time in researching potential roles and industries that might interest you. Linked in is a very powerful tool for reaching out to companies, with will mostly be more than happy to receive enthusiastic and skilled individuals such as those completing a PhD. Even if a role is not advertised, just contacting potential companies is a great way to potentially craft a more bespoke placement that suits what you are trying to get out of the experience.

Jake Leese – Oxitec

Jake is a PhD student at the University of Leeds who completed his PIPS placement at at Oxitec’s UK facility in Milton Park, Oxfordshire. Oxitec are a company that have been leading the way in the use of genetically modified insects as a tool for targeted pest control in areas of global health and agriculture. The most advanced of their projects is with the mosquito Aedes aegypti that transmits several viral diseases including Dengue, Zika and yellow fever. Oxitec’s FriendlyTM Aedes aegypti have been through field trials in Brazil, Panama, Cayman Islands and Florida, and are even now commercially available direct to consumers in Brazil.

The featured image is of the Molecular Building at Oxitec.

What did you do?

My placement was split into three rotations that gave me a broad overview of the work that is required to develop and maintain Oxitec’s transgenic insects. The first of these rotations was within the molecular lab, where transgene constructs are designed and transgenic individuals are genotyped to assess the viability and safety of candidate strains. The molecular team also support field trials by genotyping trap samples to monitor the spread of the transgene in wild populations. My work primarily involved DNA extractions and a variety of PCR reactions to support these tasks across several projects.

My second month was spent with the mass rearing team whose job it is to scale up insect production for future field release. I was brought into the team during a proof of concept experiment to produce 20,000 soy bean looper adults a week. This is a species of moth whose larval stage represents a serious agricultural pest in the Americas. Much of the day to day work revolved around preparing the diet and plastic housing for the larvae, and harvesting the pupae for adult cages before their eclosion. We also had to contend with consistent drawbacks from mould and viral outbreaks. We ran experiments alongside to try and establish the most efficient conditions for producing the best insect yield.

Mosquito Larva Screening

My final month was with the mosquito strain development team. Here I was performing micro-injections on Anopholes mosquito eggs, attempting to generate transgenic lines. I supported the team in maintaining and penetrance testing new lines, as well as screening the offspring larvae of injected mosquitos for first generation transgenics. The transgene includes a DsRed fluorescent marker so that the transgenic insects can easily be distinguished from their wild type counterparts.

Transgenic Larva

What made you want to do that particular placement?

I wanted to get a taste for R&D work within an industry setting and Oxitec is one of the few companies I came across that could offer this whilst combining two areas of biology that I am particularly interested in, insect biology and genetics.

How did you go about finding and planning your PIPS?

For a while I was scanning through the directory of biotech companies listed in biopharmguy.com. I had reached out to several companies with no luck and then I happened upon a BBC article about Oxitec’s Aedes aegypti field trial in Florida and was immediately drawn to the company’s science and objectives.

After I saw this, I found out that an old post-doc from a partner lab at Leeds was now working there. I reached out to her and she helped bring it all together and became my key host contact throughout. This was very fortunate and reinforced the importance of having good connections.

What have you gained from doing your PIPS?

My time at Oxitec gave me a great insight into an industry R&D setting. Having worked in three different areas of the company and across several different projects at differing stages of development, I gained a clear overview of how the company operates. I was also lucky enough to attend two presentations by the CEO of the company whilst I was there which gave me a great perspective of how the technology was being field tested and rolled out abroad.

As well as an appreciation for the inner workings of the company, I developed a wide range of new research skills. My experience moving between labs also gave me a deeper appreciation for the subtle differences that team dynamics and communication can make in research.

Mosquito Blood Plates

How would you sum up your PIPS experience?

My time working at Oxitec showed me first-hand how my skills can be applied directly to tackling real world problems. The rotations gave me a good variety of experience across several different scientific disciplines and meant I was consistently being challenged over the course of the internship. The PIPS has provided me with a refreshing break from the PhD and I’m now going back to my own project with a new perspective and enthusiasm.

What advice would you give other PGRs about PIPS?

When you are looking, think about where you may have contacts already as this will help you get your foot in the door. That being said, there’s no harm in contacting places regardless of whether you know anyone there. Perhaps most importantly, don’t be afraid to keep asking questions throughout your internship… The better understanding you have of what you are doing, the more you will get out of the experience.

Egle Beigaite – CasZyme

Egle Beigaite is a 4th year PhD student at the University of York who completed her PIPS placement at CasZyme, a biotech company based in Vilnius, Lithuania. CasZyme are an organisation whose research focuses on revolutionising the field of CRISPR-based Molecular Tools.

The featured image is of Egle with her PIPS colleagues.

What did you do?

My project focused on the characterisation of Cas proteins which could be used in genome editing. The techniques that I was exposed to included: colony PCR, protein purification using AKTA system (Ni and Heparin columns for affinity purification), bacterial cell transformation, cloning, RNA, DNA and plasmid purification using minipreps and midi preps. One of the main aims of my project was to determine the optimal growth and expression conditions for bacterial cells, which were then used to purify Cas proteins. I was also introduced to RNA synthesis (in vitro transcription), Cas protein and gRNA complex assembly as well as Cas activity assays.

What made you want to do that particular placement?

While relatively recent, CRISPR genome editing technology is becoming the main workhorse for genome editing in both academia and industry. Dr Gasiunas, who established the company, has previously worked in Prof. Siksnys’s lab and published several key papers in CRISPR research (Gasiunas et al 2012; Karvelis et al 2015; Gasiunas et al 2020). Prof. Siksnys, together with Prof Charpentier and Prof Doudna have received a prestigious Kavli prize for his independent development of CRISPR. I believed that it was the best accessible location for me to deepen my understanding in CRISPR technology and learn new protein characterisation techniques. In addition, this is a start-up company with only 10 employees. I thought that, by starting in such a small company, it would be easier for me to adapt and would also allow me to learn more things.

Egle working at CasZyme

How did you go about finding and planning your PIPS?

Initially, I picked two countries I believed I could easily find an internship: the Netherlands and Lithuania (I am originally Lithuanian and started search way before COVID began), and researched biotech companies in both countries. After the interviews, I received two offers from Centre for Human Drug Research (CHDR, Netherlands) and CasZyme (Lithuania). Eventually, I chose to go to work for CasZyme as I really wanted to broaden my understanding of CRISPR technology.

Regarding CHDR, my project there would have focused on neurological conditions, which is what my PhD project is about, so I found it less interesting (although it seemed like an amazing place to learn new things).

What have you gained from doing your PIPS?

I have become more confident with working with large number of samples and have also learnt how to prioritise the experiments and to perform them as efficiently as possible. In addition, I have learnt how to use AKTA protein purification system and performing CRISPR complex assembly and Cas protein activity assays (which are performed in RNAase-free box).

I also gained invaluable experience in working as part of a small biotech company and learnt first-hand the importance of collaboration and teamwork. To ensure that projects were finished according to the deadlines, experiments were efficiently redesigned and redistributed to several staff members. I learned that great communication and flexibility with your team members is extremely important, as these people also teach you new techniques and can also help you to troubleshoot.

How would you sum up your PIPS experience?

Of course, pandemic has made it a bit more difficult to travel, but I am glad I did my PIPS in CasZyme as it was great experience. I have learnt a lot of new techniques and developed friendly relationship with my colleagues. My primary laboratory manager planned the project in such a way that allowed me to learn as much as possible during my placement and made the internship comfortable during these difficult post-pandemic times. I really enjoyed being part of research team and part of CasZyme community.  Most of the staff were of my age, some also doing industrial PhDs. It was great to share the experience and support each other.

What advice would you give to other PGRs about PIPS?

Don’t be afraid to explore options outside your project (and comfort zone)! PIPS are aimed to help you learn new things, and add extra skills on your CV. I would personally recommend testing yourself in industry to see if you could work in a team with other people. The experience is also beneficial to see how industrial projects are managed and how things are generally organised (it might be quite different from your lab). I would recommend starting in a relatively small industrial company, as usually these biotechs are highly collaborative with academia and thus the working environment is slightly closer to the PhD in academia. Also, it means that you will be able to meet most of the staff during the placement and learn from them as much as possible.

Amy Stonadge (nee Brown) – LAMP Labs

Amy Stonadge (nee Brown) is a PhD student at the University of York who took part in a 3-month placement in the new COVID-19 LAMP Labs at the University of York. The LAMP Labs are a new collaboration between the University, Capita and the NHS and are working to establish a COVID-19 testing laboratory for frontline NHS staff. Read on to find out more about Amy’s PIPS experience!

Read moreAmy Stonadge (nee Brown) – LAMP Labs