PhD Projects

Our students are studying diverse areas of mechanistic biology in the following BBSRC strategic themes:

Advancing the frontiers of bioscience discovery:

1) Understanding the rules of life (formerly World Class Underpinning Bioscience)

2) Transformative technologies (formerly Exploiting New Ways of Working)

Tackling strategic challenges:

3) Bioscience for sustainable agriculture and food (formerly Agriculture and Food Security)

4) Bioscience for renewable resources and clean growth (formerly Industrial Biotechnology and Bioenergy)

These are the new BBSRC priority areas, taken from strategic document, “Forward look for UK Bioscience”, available on the BBSRC website:

NameProject title
Malika Zahedi

Smooth muscle myosin filament assembly and disassembly in smooth muscle cells: fact or fiction?
Gina Vong

The Perfect Sunrise: The effect of morning light on disease resistance in greenhouse crops
Taya Bosson

Perineuronal nets as a barrier to α-synuclein neuronal internalisation
Sude Uyulgan

In vitro generation of limb-like cells
Sophie Groenhof

A novel opportunity to combat the global Phosphorus crisis: investigating structure function relationships of an atypical phosphatase in soil bacteria
Sophie Fountain

Understanding the mechanobiology of DNA-protein interactions at the single-molecule level
Rob Hunton

Understanding the role of intracellular trafficking in in vivo cell polarisation during tissue patterning using state-of-the-art imaging and gene manipulation tools
Miguel Aracena Velazquez

Investigating the structural and mechanistic basis for translation initiation in Enterovirus Type I IRESs
Mawgan Trebell

How does S. pneumoniae acquire extracellular DNA from its natural environment to drive antibiotic resistance?
Matthew Craske

Uncovering the evolutionary impact of Gene Transfer Agents (GTAs) on Rhodobacter capsulatus
Maria Pattichis

Elucidating mechanisms regulating pathogen virulence and plant defence in the Botrytis cinerea-Arabidopsis thaliana interaction
Lorraine Matandirotya

Elucidating the role of host cell non coding RNAs in viral replication
Katie Shaw

Silicon enhances stomatal function and protects crop yields
Karla Cardenas Gomez

Going back in time to predict the evolution of a future plant pathogen
Jordan Dialpuri

Automated model building of protein-nucleotide complexes using X-ray data and Alphafold models
Joe Parr

Delineating insulin-action pathways
Jake Kerrison

Engineering proteins for applications in biosensors
Jack Connor

Navigating Through Sequence Space to Understand Alpha-Synuclein Aggregation
Harry Tran

Probing a novel allosteric binding site in Mycobacterium DNA gyrase to tackle TB and antimicrobial resistance
Gillian Caalim

Activation of the transcription factor HIF-1 by HMGN1 in Acute Myeloid Leukaemia
Eve Anderson

Cell engineering and analytical strategies for control of recombinant biopharmaceutical aggregate levels in cell culture media
Eshita Sengupta

Investigating novel mechanical receptors in the sensory nervous system
Erin Tait

Bioinspired multivalent glycan structures to decipher pathogen immune evasion
Emily Booth

Engineering a membrane-adapted viral helicase nanopore
Ella Reid

Electrochemical High-Throughput Discovery of Novel Lytic Polysaccharide Monooxygenase Enzymes (i-CASE)
Elisa Nightingale

Covalent inhibition of deubiquitiases of Leishmania mexicana
Eilidh Ward

Molecular function and evolution of long non-coding RNA derived micro-peptides in normal neuronal differentiation
Dylan Lewis

Studying the transient nature of protein binding within the electron transport chain
Daniel Narino Rojas

Developing phage therapy to reduce plant pathogen virulence in Ralstonia solanacearum
Daisy Theobald

Revealing the role of cellular non-coding RNAs in human papillomavirus (HPV) infection in oral keratinocytes
Chloe Atkins

Using Combinatorial Selection Methods to Identify Chemical Modifications of Protein Function
Chandra Ramalingam

Community metaproteomics to establish functional responses within the oral microbiome
Brianna Woodbury

Cryo-EM analysis of DNA packaging by the FtsK-HerA ATPases of dsDNA viruses
Ashleigh Whelan

How do we make and process the RNA involved in DNA repair?
Anyah Settle

Explore & develop bioanalytical methodologies to monitor the physical stability of co-formulated drug product
Anamika Kumari

Mechanistic study of organellar genome replication in malarial parasite
Alex Ascham

Engineering ATP-Grasp Enzymes for the Preparation of Pharmaceutical Amides
Tom Cozens headshotTom Cozens

Form and function: adapting dendritic morphology and synaptic location to optimise neural activity
Gemma Banister headshotGemma Banister

Molecular assembly of the non-canonical inflammasome
Matt Marsden headshotMatthew Marsden

Understanding the molecular basis of gravitropism and growth angle control
Andrew Cowan headshotAndrew Cowan

Targeting enzymes for plastic degradation
Jacob WebbJacob Webb

Revealing the targets and mode of action of plant fungicides using chemical proteomic tools (i-CASE)
Isobel Jackson HirstIsobel Jackson Hirst

Developing new approaches and improved technologies for the study of membrane protein structure and mechanism (i-CASE)
White Rose BBSRC DTP logo smallSebastian Ross

Next generation sustainable dsRNA biopesticides (i-CASE)
Nikita Soni headshotNikita Soni

Exploring a novel biological role of the master energy homeostasis regulator PGC-1alpha as a potential modifier of mitochondrial function and senescence (i-CASE)
Gabriele Gelezauskaite headshotGabriele Gelezauskaite

Investigating the cell-type-specific effects of aneuploidy using human pluripotent stem cells as a model (iCASE)
Maud de Kinderen headshotMaud De Kinderen

Exploiting an Amaranth MAGIC population for improvement of leafy vegetable traits (i-CASE)
White Rose BBSRC DTP logo smallAvril Strachan

Enhancing motor protein performance for nanopore DNA sequencing via directed and Darwinian evolutionary approaches (i-CASE)
Foteini Bifsa headshotFoteini Bifsa

Unraveling the mechanism of a peroxisomal ABC transporter
Helena Roy-Boada headshotHelena Roy Boada

Investigating how dysregulation of ncRNA networks enhance virus replication