PhD Projects

Our students are studying diverse areas of mechanistic biology in the following BBSRC strategic themes:

Advancing the frontiers of bioscience discovery:

1) Understanding the rules of life (formerly World Class Underpinning Bioscience)

2) Transformative technologies (formerly Exploiting New Ways of Working)

Tackling strategic challenges:

3) Bioscience for sustainable agriculture and food (formerly Agriculture and Food Security)

4) Bioscience for renewable resources and clean growth (formerly Industrial Biotechnology and Bioenergy)

These are the new BBSRC priority areas, taken from strategic document, “Forward look for UK Bioscience”, available on the BBSRC website:

https://bbsrc.ukri.org/documents/forward-look-for-uk-bioscience-pdf/

	Name	Project title
	Paul Bond University of York 2016	Next generation computer software for placing atoms in electron density maps
	Thomas Burns University of Sheffield 2016	Exploiting the value of the extremophile red alga Galdieria for Industrial Biotechnological benefits: White Rose BBSRC DTP Studentship Network in Industrial Biotechnology & Bioenergy
	Robert Smith University of Sheffield 2016	Functional analysis of a novel peptidoglycan binding domain conserved in Gram-positive nosocomial pathogens
	Kirsty Smitten University of Sheffield 2016	Antibacterial theranostics based on luminescent metal complexes
	Lukas Jasaitis University of Sheffield 2016	Self-assembled magnetic nanoparticle arrays: Rod-like scaffold proteins to precisely template the spatial organization of biomineralisation proteins.
	Harry Wood University of Sheffield 2016	The role of non active-site residues in enzyme catalysis
	Adam Brooks University of Sheffield 2016	Mechanistic studies of bacterial chromosome segregation using single-molecule microscopy
	Ainhao Dafis-Sagermendi University of Sheffield 2016	Electron cryo-microscopy (cryoEM) of sub-cellular assemblies
	Magdelena Dabrowska University of Sheffield 2016	Light regulation of gene expression and inter-tissue signaling
	Sarah Carroll University of Sheffield 2016	Shifting Shape with Cell Walls: Imaging the Dynamics of Guard Cell Movement
	Sarah Flannery University of Sheffield 2016	Role of nanodomains in compartmentalisation of electron transport functions in plant photosynthetic membranes.
	Peter Walker University of Sheffield 2016	Killing bacterial pathogens with blue light
	Matthew Hughes University of Leeds 2016	Harnessing the potential of extremophilic proteins from Galdieria through mechanistic insights into their stability and aggregation propensity
	Alexander Wright University of Leeds 2016	Exploiting extremophilic proteins as robust biological components for advanced biomaterials
	Emily Turri University of Leeds 2016	A synthetic biology approach to the production of terpenoids by pathway engineering.
	Amelia Shaw University of Leeds 2016	Arenavirus RNPs and Specialized Ribosomes
	Oliver Prosser University of Leeds 2016	Analysis and inhibition of chikungunya virus replication
	Philip Kirk University of Leeds 2016	Unlocking intercellular channels from cell wall biology to biophysics
	Tomasz Kaminski University of Leeds 2016	The rainbow cell – enabling technologies for immunofluorescence of living cells
	Marcus Holt University of Leeds 2016	Understanding the structure and function of ASPM, a protein essential for normal mitosis.
	James Henderson University of Leeds 2016	Towards a crystal structure of the Family B GPCR PTH2
	Sarah Good University of Leeds 2016	Understanding and Controlling Protein Aggregation and Disease: Molecular Mechanisms in vitro and in vivo
	Michael Davies University of Leeds 2016	Cellular interactions with amyloid fibrils: cytotoxic and protective mechanisms
	Matthew Chadwick University of Leeds 2016	A multi-disciplinary approach to understanding the mechanisms that limit exercise tolerance
	Michaela Agapiou University of Leeds 2016	Dissecting the mechanisms of translational regulation in Drosophila germ stem cells
	Philip Brailey University of York 2015	Can soil microbial diversity mitigate water stress and maintain crop yield in agricultural systems?
	Alexander Haworth University of York 2015	Proteolytic processing of sodium channel ß1 subunits
	Emma Stewart  University of York 2015	Nuclear matrix support of DNA replication and transcription
	Megan Sorensen University of Sheffield 2015	Metabolic mechanisms of (photo)synthetic symbiosis
	Caroline Pearson University of York 2015	The biological role and structure functio analyses of 0-antigen modifying enzymes in the bacterial pathogen Salmonella
	Alexandra Males University of York 2015	Chemical disruption of the 0-GlcNAc modification in the context of neurodengeration
	Nathaniel Holman University of York 2015	Protein 0-glycosylation enzymes as targets for novel antimicrobials against mycobacteria
	Rebecca Hall  University of York 2015	The microbiome of the tsetse
	Tobias Cracknell University of York 2015	Revealing IGFN1 functional roles through in vivo CRISPR/CAS targeting and in vitro mechanical protein unfolding
	Elizabeth Parker University of Sheffield 2015	The role of AMF in drought alleviation in crops: identifying the underpinning physiological mechanisms
	Samir Morsli University of Sheffield 2015	Establishing a novel in vivo model of stress-induced senescence using zebrafish larvae
	Julia Morris University of Sheffield 2015	The roles of a poorly characterized protease in rescuing the genome from protein linked DNA breaks
	Thomas Puttick University of Sheffield 2015	Global control of enzyme activity in the food-borne human pathogen Campylobacter jejuni: Application of high-resolution mass spectrometry to reveal novel post-translational modifications
	Peter Bancroft University of Sheffield 2015	Mycobacterium bovis aconitase-IRE interactions: integrating iron, oxidative and nitrosative stress responses
	James Bradley University of Sheffield 2015	Discovery and analysis of effector genes in the parasitic weed S. asiatica; a multi-faceted genomics approach
	Christopher Banyard University of Sheffield 2015	Investigation of a regulatory iron-sulfur complex in a bacterial sigma factor
	Rebecca Ley University of Sheffield 2015	The role of phosphorylation in regulating the activity of human flap endonuclease 1
	Eleanor Healicon University of Sheffield 2015	The Mechanics of Shape Change in Plants
	Harriet Knafler University of Sheffield 2015	Investigating the role of endocytosis in the virulence of Candida albicans
	Milena von und zur Muhlen University of Sheffield 2015	Bacterial “presisters” – Antibiotic tolerance in action
	David Farmer University of Sheffield 2015	Nanodissection of protein-protein interactions in energy transducing membrane protein complexes
	Katie Ward University of Leeds 2015	Mechanistic understanding of wheat productivity in relation to water supply using real-time moisture sensors and models
	Anna Stikane University of Leeds 2015	Advancing Biotechnologies for Fuel Generation: Exploiting Transmembrane Cytochromes for Solar Energy Conversion
	Jaskiran Sabharwal University of Leeds 2015	Is the capture of RNA by RNase E and not its cleavage the major initiator of mRNA turnover
	Catherine Kendall University of Leeds 2015	Analysis and inhibition of chikungunya virus replication