PhD Projects

Our students are studying diverse areas of mechanistic biology in the following BBSRC strategic themes:

Advancing the frontiers of bioscience discovery:

1) Understanding the rules of life (formerly World Class Underpinning Bioscience)

2) Transformative technologies (formerly Exploiting New Ways of Working)

Tackling strategic challenges:

3) Bioscience for sustainable agriculture and food (formerly Agriculture and Food Security)

4) Bioscience for renewable resources and clean growth (formerly Industrial Biotechnology and Bioenergy)

These are the new BBSRC priority areas, taken from strategic document, “Forward look for UK Bioscience”, available on the BBSRC website:

https://bbsrc.ukri.org/documents/forward-look-for-uk-bioscience-pdf/

	Name	Project title
	Michael Davies University of Leeds 2016	Cellular interactions with amyloid fibrils: cytotoxic and protective mechanisms
	Matthew Chadwick University of Leeds 2016	A multi-disciplinary approach to understanding the mechanisms that limit exercise tolerance
	Michaela Agapiou University of Leeds 2016	Dissecting the mechanisms of translational regulation in Drosophila germ stem cells
	Philip Brailey University of York 2015	Can soil microbial diversity mitigate water stress and maintain crop yield in agricultural systems?
	Alexander Haworth University of York 2015	Proteolytic processing of sodium channel ß1 subunits
	Emma Stewart  University of York 2015	Nuclear matrix support of DNA replication and transcription
	Megan Sorensen University of Sheffield 2015	Metabolic mechanisms of (photo)synthetic symbiosis
	Caroline Pearson University of York 2015	The biological role and structure functio analyses of 0-antigen modifying enzymes in the bacterial pathogen Salmonella
	Alexandra Males University of York 2015	Chemical disruption of the 0-GlcNAc modification in the context of neurodengeration
	Nathaniel Holman University of York 2015	Protein 0-glycosylation enzymes as targets for novel antimicrobials against mycobacteria
	Rebecca Hall  University of York 2015	The microbiome of the tsetse
	Tobias Cracknell University of York 2015	Revealing IGFN1 functional roles through in vivo CRISPR/CAS targeting and in vitro mechanical protein unfolding
	Elizabeth Parker University of Sheffield 2015	The role of AMF in drought alleviation in crops: identifying the underpinning physiological mechanisms
	Samir Morsli University of Sheffield 2015	Establishing a novel in vivo model of stress-induced senescence using zebrafish larvae
	Julia Morris University of Sheffield 2015	The roles of a poorly characterized protease in rescuing the genome from protein linked DNA breaks
	Thomas Puttick University of Sheffield 2015	Global control of enzyme activity in the food-borne human pathogen Campylobacter jejuni: Application of high-resolution mass spectrometry to reveal novel post-translational modifications
	Peter Bancroft University of Sheffield 2015	Mycobacterium bovis aconitase-IRE interactions: integrating iron, oxidative and nitrosative stress responses
	James Bradley University of Sheffield 2015	Discovery and analysis of effector genes in the parasitic weed S. asiatica; a multi-faceted genomics approach
	Christopher Banyard University of Sheffield 2015	Investigation of a regulatory iron-sulfur complex in a bacterial sigma factor
	Rebecca Ley University of Sheffield 2015	The role of phosphorylation in regulating the activity of human flap endonuclease 1
	Eleanor Healicon University of Sheffield 2015	The Mechanics of Shape Change in Plants
	Harriet Knafler University of Sheffield 2015	Investigating the role of endocytosis in the virulence of Candida albicans
	Milena von und zur Muhlen University of Sheffield 2015	Bacterial “presisters” – Antibiotic tolerance in action
	David Farmer University of Sheffield 2015	Nanodissection of protein-protein interactions in energy transducing membrane protein complexes
	Katie Ward University of Leeds 2015	Mechanistic understanding of wheat productivity in relation to water supply using real-time moisture sensors and models
	Anna Stikane University of Leeds 2015	Advancing Biotechnologies for Fuel Generation: Exploiting Transmembrane Cytochromes for Solar Energy Conversion
	Jaskiran Sabharwal University of Leeds 2015	Is the capture of RNA by RNase E and not its cleavage the major initiator of mRNA turnover
	Catherine Kendall University of Leeds 2015	Analysis and inhibition of chikungunya virus replication
	David Kealy University of Leeds 2015	How does the human papillomavirus (HPV) E5 protein control skin cell growth and differentiation during a productive life cycle?
	Nicholas Hurst University of Leeds 2015	Molecular basis for specific regulation of the stress sensor IRE1 in cancer cells
	James Horne University of Leeds 2015	Chaperone-assisted protein folding in the bacterial periplasm
	Francis Hopkins University of Leeds 2015	Structural Biology of RiboNucleoProtein complexes of pathogenic arena and bunyaviruses
	Sophie Hesketh University of Leeds 2015	Developing our structural understanding of the TRPM2 channel through electron microscopy studies
	Brittany Graham University of Leeds 2015	Muscle ageing and gene expression balance in Caenorhabditis elegans
	Jack Bravo University of Leeds 2015	Mechanism of Genomic Segment Assortment in Avian Reovirus
	Peter Fisher University of York 2014	Predicting glycan alterations in mammalian cells
	Emily Breardon University of Sheffield 2013	Discovery and functional analysis of Striga resistance genes in rice for targeted breeding of durable defence.
	Matthew Dooley University of Leeds 2014	Improving methods for the detection and monitoring of beetle pests through a deeper understanding of the mechanisms underlying beetle odour perception.
	Lia De Faveri University of Leeds 2014	Synthetic approaches to developing reagents for rapid, in-field detection of cereal rusts
	Emma Wroblewski University of Leeds 2014	Defining a novel assembly pathway in ssRNA viruses.
	Brendan Rogers University of Leeds 2014	The Structural Biology of the Z-disc in health and disease
	Grace Roberts University of Leeds 2014	Investigating the role of the nsP3 macro domain in Chikungunya virus replication
	Alistair Plant University of Leeds 2014	Co-Repression and the Evolution of Novel Plant Structures
	Ryan Kaye University of Leeds 2014	The Mechanisms of Gravity-Dependent Non-Vertical Growth in Higher Plants
	Alexander Coleman University of Leeds 2014	Virus remodelling of the nuclear pore complex : a novel antiviral target
	Lucy Barber University of Leeds 2014	New approaches to combatting amyloid disease from mechanistic insights
	Joseph Ward University of Leeds 2014	Understanding foot-and-mouth disease virus (FMDV) replication
	Samuel Bunce University of Leeds 2014	Developing Diazirines as Probes for Monitoring Dynamic Molecular Recognition Processes
	Simon Fairbanks University of Sheffield 2014	Structural studies on luminescent probes for quadruplex DNA
	Elanor Harrison University of Sheffield 2014	Studying the roles of epigenetics in therapeutic protein production