My project

In all forms of life, DNA must be properly segregated to each daughter cell for the stable inheritance of genetic material during cell division. Recent advancements in fluorescence microscopy have revealed that bacterial chromosomes are highly organized and segregate with distinctive patterns in the cell. Most bacterial chromosomes and low copy number plasmids including those that carry antibiotic resistance and virulence encode the Par system to mediate DNA segregation. The aim of the project is to gain novel insight into the molecular mechanisms underpinning bacterial chromosome segregation. The project will investigate the interplay of the partition proteins of the Par system and how they are involved in driving chromosome movement and positioning. The project combines multidisciplinary approaches including biochemistry, bacterial cell biology and single-molecule fluorescence microscopy to visualize the spatial dynamics of partition proteins and chromosomes.

Connect

Not yet available.