Yorkshire Bioscience DTP – Projects for October 2025

HostPrimary SupervisorProject title
BradfordAmalia Ruiz EstradaHarnessing mechanotransduction using magnetic nanoactuators to elicit cellular responses
BradfordJacobo EliesInvestigating molecular determinants of cellular fate driven by air pollutants
BradfordKarthic SwaminathanDeciphering the molecular mechanisms of mechanosensing in stem cell homeostasis and differentiation.
BradfordSneha SwaroopUnderstanding the interplay between endogenous endocrine signalling molecules and exogenous mimetics in normal breast and stem cells: An advanced model system approach. 
BradfordStuart DickensInvestigating perineuronal nets modulation as a mechanism underlying diet induced cognitive impairment
BradfordVibhu JhaIntegrated computational and biochemical investigation of EGFR-mediated cell signaling
HullAndré VoelzmannHow does cross play of DNA replication, packaging and innate immune response determine assembly efficiency of viral vectors for gene therapies?
HullDarron CullenNurture versus nature in locusts – can we control their swarming behaviour?
HullDomino Joyce Seeing the light: how the dynamic structure of rhodopsin enables deepwater vision.
HullGraham FerrierRevolutionising Early Detection of Crop Pathogenesis using AI-based analysis of digital Imagery.
HullJen BrightThe functional consequences of intra- and interspecific variation in the material properties of bird bone
HullMat HardmanModulating the ageing skin microbiome with cold atmospheric plasma
HullMauro Adriel RinaldiSynthetic organelles for biofuel biomanufacturing from waste biomass
HullPaul HiebertA Next-Generation 3D Skin Model for Insights into Healthy Aging
LeedsAde WhitehouseVirus modification of nuclear condensates: understanding their role during infection
LeedsAmanda BretmanIt’s getting hot in here: how heatwaves impact health and ageing
LeedsAndrew MacdonaldMechanisms of long non-coding RNA function in the human papillomavirus life cycle in primary epithelial tissues
LeedsAntonio CalabreseOvercoming host cell protein contamination in the preparation of biopharmaceuticals
LeedsAntreas KalliUnderstanding how force is sensed in cells by the Piezo2 mechanosensitive channel 
LeedsBruce TurnbullExploring Protein-Glycan Interactions with Fluorinated Carbohydrates
LeedsCharlie ScarffUnravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy
LeedsEszter CsibraBuilding orthogonal ribosome control for engineering biology
LeedsGraham AskewUnravelling the mechanical function of the leg muscles during running
LeedsIoannis DelisMultisensory decision-making in the developing and aging human brain
LeedsJoe CockburnThe seminal fluid extracellular matrix: a new paradigm in reproductive biology?
LeedsJulie AspdenDissecting mechanisms of translational regulation by specialised ribosomes
LeedsMichelle PeckhamMaking and breaking myosin filaments: How smooth muscle cells modulate their contractile behaviour.
LeedsNeil RansonUnderstanding protein aggregation in human pancreatic tissue 
LeedsP. E. UrwinTranslating the chemical cross-talk between plants and root symbionts through application of novel microfluidics devices
LeedsPaul BealesDynamics of metabolically-active biomolecular condensates
LeedsPete WatsonInvestigating the structural optimisation of bone through computational biomechanical modelling 
LeedsRalf RichterSuperselective targeting of perineuronal nets in the brain
LeedsRichard BaylissProbing covalent mechanisms of regulation and inhibition in mitotic kinases
LeedsRobin BonIn situ studies of localisation, structure and interactions of TRPC5 ion channels
LeedsRyan SeipkeEavesdropping on the molecular dialogue between a standalone cyclase and its cognate nonribosomal peptide synthetase
LeedsScott BowenPiezo1 as a novel mechanosensor regulating skeletal muscle fatigue and adaptation to exercise 
LeedsSimon GoodmanNovel biosensor technology for environmental surveillance of emerging infectious diseases 
LeedsTakashi OchiStructural studies of DNA double-strand break repair in plants
LeedsTom BennettUnderstanding the molecular and physiological basis for crop-weed interactions for sustainable agriculture
LeedsViktor LukacsCharacterisation of a novel molecular temperature receptor
LeedsYuan GuoElucidating lectin receptor signalling balance in dendritic cell function modulation in health and disease 
Leeds BeckettAngela OatesRespired Microplastics: Unveiling Hidden Infection and Cellular Risks
Leeds BeckettArya GuptaPiggybacking off ion-channel inhibitors to enhance activity of clinically relevant antibiotics against staphylococci
Leeds BeckettJaskaren KohliAgeing and Infection: Does RNA sensing play a key role?
Leeds BeckettJessica HaighDo insulin-resistant cells provide a favourable hiding place for bacteria?
Leeds BeckettMatt HindleThe functional, metabolic and molecular cortisol-induced reprogramming of platelets
Leeds BeckettWayne RobertsEvaluating Platelet Microparticles as Novel Regulators of Vascular Health (PULSE)
Leeds BeckettZoe KolokotroniDrivers of Food Consumption: Circadian Rhythm and Sleep–Wake Alterations in Eating Behaviour, and Metabolism.
SheffieldAndrew FlemingThe functional role of the epidermis in stomatal function
SheffieldAndrew HitchcockExploring the structure and dynamics of Complex I and ATP synthase in phototrophic bacteria
SheffieldAnestis TsakiridisDeciphering the role of biomechanical cues in embryonic cell fate decisions using human pluripotent stem cells
SheffieldChris CooneyUsing Artificial Intelligence to Reveal the Signature of Development in Organismal Colour Pattern Designs
SheffieldDan BoseUnveiling the Secrets of Intrinsically Disordered Proteins in Gene Regulation
SheffieldEllie HarrisonPredicting pathogen evolution: using experimental evolution to understand the impact of phage therapy on Clostridioides difficile
SheffieldErin CuttsDeveloping Imaging Solutions to Study the Dynamics of Human Condensin I
SheffieldHelen MatthewsThe role of keratin networks in maintaining tissue epithelial tissue integrity
SheffieldHenry RoehlRegulation of regeneration by TGFbeta and SFKs
SheffieldIan LidburyExploring bacteria-mycorrhizal fungi-plant interactions regulating nutrient exchange
SheffieldIan SudberyThe regulatory mechanisms of 3’ UTR introns in stem cell differentiation
SheffieldIvana BarbaricThe impact of mechanical stress on the genome maintenance in pluripotent stem cells
SheffieldIwan EvansMining white blood cell diversity to enhance phagocytosis
SheffieldKatie FieldOptimising wheat-fungal symbioses for enhanced nutrition and sustainability
SheffieldLisa SmithSignalling complexes and cell wall changes during plant reproduction 
SheffieldLuke DunningHorizontal gene transfer and its role in crop adaptation and evolution
SheffieldMatt JohnsonDetermining the role of FNR location in the photoprotection of photosystem I
SheffieldMatthew NewtonHow does non-coding RNA structure regulate gene expression?
SheffieldMatthew TowersInvestigating a polarity switch in bird wing feather development
SheffieldMike WilliamsonDeciphering the mechanism of Plasmodium apicoplast lagging strand replication
SheffieldMirre SimonsMechanisms of alternative splicing in neurodegeneration and ageing
SheffieldNadav AmdurskyDeciphering proton shuttling on the surface of biological membranes toward proton translocating channels
SheffieldNicola NadeauThe genetic and developmental control of complex nanostructure formation in butterfly wing scales
SheffieldPer BulloughMechanism of phage infection in the C. difficile pathogen- towards effective phage therapy
SheffieldSam AmsburyPrimed for Protection: Cell Wall Modifications in Plant Defense and Long-Term Immunity
SheffieldSam CatonBiological drivers of health inequalities: impact of diet on the gut microbiome in preschool children.
SheffieldStuart WilsonUnderstanding the structure of mRNA in vivo
SheffieldTim CraggsPredicting the structural ensembles of Intrinsically Disordered regions of proteins: The “alpha-fold” for IDRs
Sheffield HallamAlexandra MalesExploring enzyme-mediated degradation of plant biomass by in situ imaging for biosecurity
Sheffield HallamNeil CrossMultimodal mass spectrometry imaging to visualise the glycomic and metabolomic landscape for prostate cancer metastasis to bone
Sheffield HallamNick PeakeExtracellular vesicles and the microbiome: from top to bottom
Sheffield HallamNik GeorgopoulosUse of physiologically relevant in vitro cell models for the development of biology-driven approaches to enhance the efficacy of scalp and limb cooling technologies
Sheffield HallamSimona FranceseNon-invasive detection of breast cancer from fingertip smears
TeessideCaroline OrrOptiPol – Optimised composting of poultry manure for sustainable processing of farm waste
TeessideClaudio AngioneTransformer-Bio: integrating imaging and omics in large-scale food fermentation
TeessideJamie BojkoNudivirus infection capacity across crustaceans of economic importance
TeessideKalesh KarunakaranDecoding the Cross-talk Between RNA-binding Proteins, Phosphorylation, and Molecular Chaperones in Post-Transcriptional Gene Regulation in Toxoplasma gondii.
TeessideMohammad DadashipourEngineering Biocatalysis: Unleashing the Potential of Hyper-Thermostable Phosphorylated-Sugar Nucleotide Metabolising Enzymes
TeessideOmar AboelazayemIntensified biochemical and hydrothermal biorefinery for lignocellulosic biomass valorisation: A circular economy approach (BioTherm)
YorkAlan CartmellHost glycan metabolism underpins cross-phylum food webs in the human gut microbiota
YorkAndrea HarperChemical warfare in the rhizosphere: unpicking the defensive role of plant root exudates against the bacterial pathogen Ralstonia solanacearum
YorkAndrew HoldingElucidating the Mechanism of Hypoxic Reprogramming of the Estrogen Response. 
YorkBenjamin LichmanNature’s chemist: how a plant can produce the complex and diverse Daphniphyllum alkaloids 
YorkChris MacDonaldUnderstanding evolutionarily conserved mechanisms of membrane remodelling required for photosynthesis
YorkChristoph BaumannSuper-size them bugs: Engineering a stable, elongated bacterial strain for biomanufacturing.
YorkDaniel UngarStructural characterization of vesicle tethering at the Golgi
YorkDaniela BarillàLife pushed to extremes: probing the mechanisms of chromosome segregation in thermophilic Archaea
YorkDaphne EzerAI for adaptive gene networks over plant evolution
YorkFederico SabbadinDeveloping novel insecticidal proteins for crop protection
YorkGavin ThomasUnderstanding nickel homeostasis for improved industrial enzyme production
YorkGavin WrightStructural vaccinology to improve vaccine design for the parasitic livestock disease animal African trypanosomiasis.
YorkGideon GroganBroadening the Catalytic Promiscuity of Amide Bond Synthetases using Directed Evolution and Robotic Screening
YorkHan-Jou ChenCharacterisation of the HSF1 regulatory complex
YorkIoannis KourtzelisUnravelling the role of extracellular vesicles in the orchestration of macrophage – mediated immune regulation.
YorkJamie WoodRefinement of a computational model of glycan processing and its application to datasets of medical and biotechnological relevance
YorkJoana FariaMaking sense of antigenic variation in trypanosomes: a nuclear factory with a switching problem…
YorkKanchon DasmahapatraGenetic and developmental basis of transparency in butterflies
YorkKatherine DenbyGenomics and genetics of traditional smallholder crops: amaranth and cowpea
YorkLiz RylottDeveloping plant-based solutions to recover technology-critical rare earth elements from wastes
YorkLuke AlpheyUnderstanding the role of piRNAs in mosquito immunity
YorkMartin FascioneThe sweet side of ‘evil twin’ sugars: using chemical glycobiology tools to explore the role bacterial sialic acids play in host immune evasion by pathogens
YorkMichael PlevinAccelerating protein library screening via innovative sensor arrays
YorkMichelle HawkinsHow do helicases prevent replication and transcription machinery collisions?
YorkPegine WalradInvestigating the impact of PRMT-catalysed methylation on RBP:RNA interactions, mRNP granule formation (LLPS), structural dynamics and gene regulation
YorkPurba MukherjeeMechanistic study of the assembly and repair of unique bacterial telomeres in Streptomyces
YorkSean MeadenA Farewell to Arms: The Trade-off Between Growth and Defence in Bacteria
YorkThierry TononWhy diatoms produce palmitvaccenic acid?
YorkWill BrackenburyBioelectrical control of epithelial cell behaviour