James Ronald

Setting a circadian clock: Structural understanding of the ligand-activation model of the circadian evening complex components ELF4 to ELF3

About me

I completed my undergraduate and integrated masters degree at the University of Leeds before moving to the University of York to start a PhD investigating the mechanisms surrounding light signalling to the plant circadian clock.

My project

Plant circadian rhythms facilitate the synchronisation of internal physiological responses to the predicted external time. The protein of interest to my PhD project (EARLY FLOWERING 3, ELF3) is critical for the functioning of the Arabidopsis circadian oscillator. A loss of ELF3 in Arabidopsis results in circadian arrythmicity and subsequently a series of developmental phenotypes. ELF3 is also a critical hub in light signalling to the oscillator. Light signals directly to the circadian clock in a process called entrainment. ELF3 physically interacts with red light receptors and this interaction is thought to repress ELF3 activity. Conversely, ELF3 is activated by a far red light receptor, which independently results in the inactivation of the red light receptor. My project is focused on understanding how these red and far-red light signalling pathways influence ELF3 activity at different times of the day.

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