Andrew Stone

Defining the stem cell subtypes controlling bone and blood formation

About me

I studied Molecular Cell Biology (with year in industry) at the University of York from 2012-2016. I spent my year in industry working for AstraZeneca in their Oncology DNA Damage Response research group. I have a keen interest in all science but predominantly medical biology with particular interests in haematopoiesis and the bone marrow. My research focuses on mesenchymal stromal cells and their role in the formation of blood and bone with an aim to contribute to the development of cell based therapeutics using these cells.

My project

Mesenchymal stromal cells are a highly heterogeneous population of cells known to have an array of functions in vivo. A stem cell subset, known as mesenchymal stem cells, are capable of differentiation towards bone, fat, and cartilage, therefore contributing to repair and maintenance of the skeleton. Mesenchymal stromal cells are also implicated with roles in regulation and support of haematopoiesis and the structure of the haematopoietic niche. I am using a panel of immortalised stromal cell clones to dissect the heterogeneity of these cells and understand how different subsets may contribute to the formation of bone and the regulation of haematopoiesis. I am using a variety of approaches including global proteomic and transcriptomic interrogation to understand the modes of signalling used by stromal cells and the signals they produce that could regulate blood production.