About me

During my master’s project in China, I researched the structures and bioactivities of secondary metabolites (small molecules) of various species of fungi. I used a combination of NMR and MS techniques. I am currently working on a PhD project involving cutting-edge NMR and MS technologies like ultra-high field methyl NMR and HDX-MS. This project aims to map the binding model of a protein and its inhibitor. I find it fascinating to study biomolecules and small molecules using NMR technology.

My Project

The aim of this project is to uncover the binding model and mechanism of the inhibitor of the non-mevalonate pathway TPP-dependent enzyme, 1-deoxy-D-xylulose-5-phosphate synthase (DXS). It is important to note that blocking DXS activity will cause the plant to die. Therefore, this research will help us understand potential strategies for designing inhibitors, which could lead to the development of better herbicidal agents for targeting this pathway. We will be using cutting-edge techniques such as ultra-high field methyl NMR and hydrogen-deuterium exchange mass spectrometry (HDX-MS) to carry out this research.