PhD Projects

Our students are studying diverse areas of mechanistic biology in the following BBSRC strategic themes:

Advancing the frontiers of bioscience discovery:

1) Understanding the rules of life (formerly World Class Underpinning Bioscience)

2) Transformative technologies (formerly Exploiting New Ways of Working)

Tackling strategic challenges:

3) Bioscience for sustainable agriculture and food (formerly Agriculture and Food Security)

4) Bioscience for renewable resources and clean growth (formerly Industrial Biotechnology and Bioenergy)

These are the new BBSRC priority areas, taken from strategic document, “Forward look for UK Bioscience”, available on the BBSRC website:

NameProject title
Anamika Kumari

Mechanistic study of organellar genome replication in malarial parasite
Alex Ascham

Engineering ATP-Grasp Enzymes for the Preparation of Pharmaceutical Amides
Tom Cozens headshotTom Cozens

Form and function: adapting dendritic morphology and synaptic location to optimise neural activity
Gemma Banister headshotGemma Banister

Molecular assembly of the non-canonical inflammasome
Matt Marsden headshotMatthew Marsden

Understanding the molecular basis of gravitropism and growth angle control
Andrew Cowan headshotAndrew Cowan

Targeting enzymes for plastic degradation
Jacob WebbJacob Webb

Revealing the targets and mode of action of plant fungicides using chemical proteomic tools (i-CASE)
Isobel Jackson HirstIsobel Jackson Hirst

Developing new approaches and improved technologies for the study of membrane protein structure and mechanism (i-CASE)
White Rose BBSRC DTP logo smallSebastian Ross

Next generation sustainable dsRNA biopesticides (i-CASE)
Nikita Soni headshotNikita Soni

Exploring a novel biological role of the master energy homeostasis regulator PGC-1alpha as a potential modifier of mitochondrial function and senescence (i-CASE)
Gabriele Gelezauskaite headshotGabriele Gelezauskaite

Investigating the cell-type-specific effects of aneuploidy using human pluripotent stem cells as a model (iCASE)
Maud de Kinderen headshotMaud De Kinderen

Exploiting an Amaranth MAGIC population for improvement of leafy vegetable traits (i-CASE)
White Rose BBSRC DTP logo smallAvril Strachan

Enhancing motor protein performance for nanopore DNA sequencing via directed and Darwinian evolutionary approaches (i-CASE)
Foteini Bifsa headshotFoteini Bifsa

Unraveling the mechanism of a peroxisomal ABC transporter
Helena Roy-Boada headshotHelena Roy Boada

Investigating how dysregulation of ncRNA networks enhance virus replication
Isabelle Boon headshotIsabelle Boon

Unravelling the rules of outer membrane protein folding: Opportunities for the design of new antibacterial strategies
Katie Buttriss headshotKatie Buttriss

Structural studies of DNA repair required for human immune diversity using cryoEM 
Sabina Musial headshotSabina Musial

Assembly principles of the CO2 -fixing liquid-liquid phase separated organelle, the Pyrenoid
Jack Stenning headshotJack Stenning

Defining Estrogen Receptor Binding and Response Determinants at Single-Cell Resolution
Monika Gonka headshotMonika Gonka

Understanding haematopoietic stem cell fate choices by comparing distinct cellular states
Isaac Reynolds headshotIsaac Reynolds

Future-proofing our food: Priming plants to tolerate climate change
Abigail Walklett headshotAbigail Walklett

A 'sweet' new strategy for tackling superbugs: uniting synthetic and biochemical glycoscience for the inhibition of novel carbohydrate processing enzymes in multi-drug resistant bacteria
Charles CranstonCharles Cranston

Understanding the mechanisms leading to age-related hearing loss
Rebbekah Menday headshotRebbekah Menday

Structures and Mechanisms in killing C. difficile by Bacteriophages
Will Mulcrone headshotWilliam Mulcrone

Enzymatic repair of covalently crosslinked DNA
Vincent Chan headshotTessa Chan

Investigating ribosome specialization during cellular differentiation
Emily MagkourilouEmily Magkourilou

The role of mycorrhizal fungal networks in modulating plant symbioses with plant-parasitic nematodes
Jodie ArmandJodie Armand

Swinging Stomata: 4D capture of plant cell morphodynamics to inform on wall mechanics
Peter Chong 2020 starter headshotPeter Chong

CryoEM and biochemistry-led discovery of protein nanopores for biotechnology (CASE)
Patrick Hunter 2020 starter headshotPatrick Hunter

Developing next generation bioimaging/biophotonics tools to dissect the immunological synapse in single cells, one molecule at a time
Rory Elston headshot 2020 starterRory Elston

Understanding and exploiting bacterial sugar transporters for increased production of prebiotics (CASE)
Lydia Barber 2020 starter headshotLydia Barber

Understanding receptor clustering via multivalent ligand display (CASE)
Miles Deans 2020 starter headshotMiles Deans

Using machine learning to identify aggregation resistant biopharmaceuticals (CASE)
Albert Blandy headshot 2020 starterBertie Blandy

Dissecting mechanisms of mRNA translational control by specialised ribosomes
Blythe Wright 2020 starter headshotBlythe Wright

Mechanistic dissection of interplay between membrane traffic and apoptosis by mutations in the endosomal sorting regulatory protein Vps45
Ethan Redmond 2020 starter headshotEthan Redmond

The Circadian Clock in the Ageing Plant
Jodie Malcolm 2020 starter headshotJodie Malcolm

The selective control of tRNA gene transcription by steroid receptors in breast cancer
Barbara Radzikowska 2020 starter headshotBarbara Radzikowska

Daphniphyllum alkaloid (bio)synthesis
Timothy Johnston 2020 starter headshotTimothy Johnston

Role of Sulfiredoxin-1 in maintaining neuronal function and redox homeostasis
Nathan Innard 2020 starter headshotNathan Innard

Tracking anaerobic microbial community responses using a synthetic biology approach
Lewis Byrom 2020 starter headshotLewis Byrom

Structure and function of CIZ1/RNA complexes
Eleanor Briggs 2020 starter headshotEleanor Briggs

Fungal ß-glucan cell wall biosynthesis (CASE)
Emma White 2020 starter headshotEmma White

Improving water-use efficiency in wheat by modulating leaf structure (CASE)
Jessica Hurcum 2020 starter headshotJessica Hurcum

Novel approaches for the identification of allosteric inhibitors of high value therapeutic targets (CASE)
Polly Rouse 2020 starter headshotPollyanna Rouse

Elucidating the cellular targets of BoNT/X a potentially novel biopharmaceutical (CASE)
Derek Bell 2020 starter headshotDerek Bell

Activators of microbial enzymes for enhanced C capture and decreased pathogen populations in arable soils.
Victoria Hill 2020 starter headshotVictoria Hill

The Conformational Dynamics of Two-Way DNA Junctions: A common first step in aberrant DNA recognition?
Karolina Pyrzanowska 2020 starter headshotKarolina Pyrzanowska

Biochemical and structural basis of bacteriophage tail-associated hydrolases of Diabetic Foot Ulcer AMR pathogens
Katy Boswell 2020 starter headshotKaty Boswell

Characterizing the key enhancers during the initiation of Neuroblastoma using Human Pluripotent Stem Cells
Julian Adams 2020 starter headshotJulian Adams

How increases in night-time temperature reduce seed yields