PhD Projects

Our students are studying diverse areas of mechanistic biology in the following BBSRC strategic themes:

Advancing the frontiers of bioscience discovery:

1) Understanding the rules of life (formerly World Class Underpinning Bioscience)

2) Transformative technologies (formerly Exploiting New Ways of Working)

Tackling strategic challenges:

3) Bioscience for sustainable agriculture and food (formerly Agriculture and Food Security)

4) Bioscience for renewable resources and clean growth (formerly Industrial Biotechnology and Bioenergy)

These are the new BBSRC priority areas, taken from strategic document, “Forward look for UK Bioscience”, available on the BBSRC website:

NameProject title
Liam Barratt

Future-proofing Our Food: Increasing Tolerance to Abiotic Stress in Hexaploid Bread Wheat Using Associative Transcriptomics
Megan Clarke

Primed for parasitism: pathogenic nematodes tailor their response to host plant exudates
Sameh ElBadry

Characterisation of the mechanism of HIF mediated genoprotection in zebrafish
Zoe Ingold

Engineering Carbon-carbon Bond Forming Enzymes from Plants for Applications in Industrial Biotechnology
Ezra Herman

Unravelling evolutionary mechanisms of phage-bacteria interactions in spatially structured microbial communities
Jessica Downing

Genomics-guided approaches to enzyme discovery in the extremophile Galdieria sulphuraria (i-CASE)
Madeleine Inglis

Flight Control in Birds
Egle Beigaite

Characterising a novel candidate gene regulating ageing related atrophy in neurons
Alexander Setchfield

Microbial degradation of agricultural residues as feed for black soldier fly larvae (iCASE)
Sonam Sidhu

Dissecting molecular complexity in single living cells using state-of-the-art super-resolution microscopy and biophysical chemistry, one molecule at a time
Laura Wiggins

Using machine learning to predict cell type and fate in heterogeneous populations (NPIF)
Alexander Scott

How does low-temperature plasma damage the bacterial outer membrane?
Alexander Russell

Dissecting a role for ZAK-beta in skeletal muscle development using genetics and embryology in zebrafish and Xenopus
Benjamin Rowlinson

Unravelling the structural biology of the LIMD1 scaffold protein using novel NMR approaches
Katie Greenin

Maintaining effective sensory coding in the face of inter-neuronal variation
Lianne Gahan

A new mathematical framework for Aβ peptide assembly in Alzheimer’s disease
Thomas Emrich-Mills

Developing de novo architectures of photosynthetic complexes for the control of photocurrent output from reaction centres.
Molly Patterson

Re-wiring epithelial homeostasis: Papillomavirus targeting of the Hippo signalling
Jacob Leese

Investigating the molecular mechanisms underpinning the arthropod segmentation clock
Katherine Harper

The role of circRNA dysregulation during KSHV infection
Lewis Hancock

Modelling complexity and redundancy in actin polymerization
Romany Mclure

Identifying and modulating aggregation propensity in bio-pharmaceuticals (i-CASE)
Samuel Haysom

The structure and function of the ß-barrel assembly machinery
Luke Fountain

Investigating links between plant nitrogen preference, root exudation and microbial nitrogen cycling
Catherine Russell

Investigating Bromodomain Proteins as Targets for anti-Leishmanial Drug Discovery
Amy Brown

The role of the stress kinase MLTK7 in muscle disease
Liam Maddison headshotLiam Maddison

Probing the function of RNA methylation through chemical biology (iCASE)
Rachel Greenhill

Identification and functional validation of effector genes in the parasitic weed Striga asiatica
Maria Nikolova

Mechanism and structure of the PACE family of transport proteins
Josh Lee

Probing the epitranscriptome with nanopore sequencing (iCASE)
Alice Seleiro

Uncovering underlying cellular mechanisms at work under high cell density E. coli protein production conditions in biotechnology (iCASE)
Evie Farnham

Evolution, virulence and dispersal of bacterial plant pathogen, Ralstonia solanacearum (iCASE)
Amber Emmett

Machine Learning to Predict Genetic Regulation in Blood Cells
Adam Casey

Improving pest management in coffee plantations (iCASE)
Katie West

Understanding long non-­coding RNA function
Savvas Ioannou

Engineering extracellular vesicles derived from human mesenchymal stem cells
James Forsythe

How does the circadian clock regulate disease resistance?
Ashley Hayes

Investigating How Nematodes Manipulate the Plant Secretory Pathway
John Armstrong

Borrowing building blocks from bacteria and eukaryotes: a three-component DNA segregation machinery in archaea
Rachael Cooper

How do repetitive bacterial surface proteins avoid inter-domain aggregation?
Rhianna Rowland

Imaging agents for genetic disease: structural, chemical and cellular dissection
Sarah Tindall

Structural analysis of acyltransferase proteins involved in O-antigen modification
Sarah Thorne

Improved wheat yield with silicon
Kirstin Spence

Investigating the molecular machinery that controls autophagy during Leishmania spp. Differentiation
Edward Nay

Regulation of gene expression in Leishmania parasites: structure, function and post-transcriptional modification of RNA binding proteins
Jessica Dobson

Mechanisms of palladium uptake and nanoparticle formation by plants
Grace Dobbs

Role of CIZ1 in X chromosome inactivation
Grace Cowen

Role of DNA methylation in brain function
Ana Almeida Jones

Ahead of the curve: imaging and computational analysis of shape and form in the developing zebrafish ear
Amy Tooke

Seeing is believing, observing bacterial biofilm formation in vivo