PhD Projects

Our students are studying diverse areas of mechanistic biology in the following BBSRC strategic themes:

Advancing the frontiers of bioscience discovery:

1) Understanding the rules of life (formerly World Class Underpinning Bioscience)

2) Transformative technologies (formerly Exploiting New Ways of Working)

Tackling strategic challenges:

3) Bioscience for sustainable agriculture and food (formerly Agriculture and Food Security)

4) Bioscience for renewable resources and clean growth (formerly Industrial Biotechnology and Bioenergy)

These are the new BBSRC priority areas, taken from strategic document, “Forward look for UK Bioscience”, available on the BBSRC website:

https://bbsrc.ukri.org/documents/forward-look-for-uk-bioscience-pdf/

NameProject title
Alexandra Holmes

Investigating the Structure and Function of Membrane-Integral Pyrophosphatases
Robert Brench

Speeding towards efficient stomata - the molecular mechanisms that underpin increased stomatal efficiency
Hannah Jones

Seasonality control of barley flowering: from the lab to the field (i-CASE)
Kathryn Billane

The evolution of multidrug resistant bacterial pathogens
Jessica Edge

MicroRNA evolution in placental mammals: Unravelling conservation and divergence in their regulatory mechanisms in early pregnancy in different placental mammals
Kane Yoon

Epigenetics, embryogenesis and plasticity in insects
Thomas Hamer

Molecular localisation of Staphylococus aureus surface proteins
Harry Schofield

Structural and mechanistic insights into antibiotic resistance in Staphylococcus aureus
Jessica Mcneill

Plasticity of clathrin-mediated endocytosis in development
Rosalind Latham

Nuclease-resistant DNA nanostructures for high precision plant genome engineering
Joanna Greenman

SSA Mechanisms and functional consequences of platelet-macrophage cross-talk in type 2 immunity
Emily Byrd

Probing the Conformational Dynamics of α-Synuclein by Structural Mass Spectrometry
Charlotte Stevenson

Programming the subcellular localization of enzyme inhibitors
James Barrett

Super resolution imaging of the algal pyrenoid
Claire Smithson

Epigenetic mechanisms underlying responses to environmental stress
Liam Barratt

Future-proofing Our Food: Increasing Tolerance to Abiotic Stress in Hexaploid Bread Wheat Using Associative Transcriptomics
Megan Clarke

Primed for parasitism: pathogenic nematodes tailor their response to host plant exudates
Sameh ElBadry

Characterisation of the mechanism of HIF mediated genoprotection in zebrafish
Zoe Ingold

Engineering Carbon-carbon Bond Forming Enzymes from Plants for Applications in Industrial Biotechnology
Ezra Herman

Unravelling evolutionary mechanisms of phage-bacteria interactions in spatially structured microbial communities
Jessica Downing

Genomics-guided approaches to enzyme discovery in the extremophile Galdieria sulphuraria (i-CASE)
Madeleine Inglis

Flight Control in Birds
Egle Beigaite

Characterising a novel candidate gene regulating ageing related atrophy in neurons
Alexander Setchfield

Microbial degradation of agricultural residues as feed for black soldier fly larvae (iCASE)
Sonam Sidhu

Dissecting molecular complexity in single living cells using state-of-the-art super-resolution microscopy and biophysical chemistry, one molecule at a time
Laura Wiggins

Using machine learning to predict cell type and fate in heterogeneous populations (NPIF)
Alexander Scott

How does low-temperature plasma damage the bacterial outer membrane?
Alexander Russell

Dissecting a role for ZAK-beta in skeletal muscle development using genetics and embryology in zebrafish and Xenopus
Benjamin Rowlinson

Unravelling the structural biology of the LIMD1 scaffold protein using novel NMR approaches
Katie Greenin

Maintaining effective sensory coding in the face of inter-neuronal variation
Lianne Gahan

A new mathematical framework for Aβ peptide assembly in Alzheimer’s disease
Thomas Emrich-Mills

Developing de novo architectures of photosynthetic complexes for the control of photocurrent output from reaction centres.
Molly Patterson

Re-wiring epithelial homeostasis: Papillomavirus targeting of the Hippo signalling
Jacob Leese

Investigating the molecular mechanisms underpinning the arthropod segmentation clock
Katherine Harper

The role of circRNA dysregulation during KSHV infection
Lewis Hancock

Modelling complexity and redundancy in actin polymerization
Romany Mclure

Identifying and modulating aggregation propensity in bio-pharmaceuticals (i-CASE)
Samuel Haysom

The structure and function of the ß-barrel assembly machinery
Luke Fountain

Investigating links between plant nitrogen preference, root exudation and microbial nitrogen cycling
Catherine Russell

Investigating Bromodomain Proteins as Targets for anti-Leishmanial Drug Discovery
Amy Brown

The role of the stress kinase MLTK7 in muscle disease
Liam Maddison headshotLiam Maddison

Probing the function of RNA methylation through chemical biology (iCASE)
Rachel Greenhill

Identification and functional validation of effector genes in the parasitic weed Striga asiatica
Maria Nikolova

Mechanism and structure of the PACE family of transport proteins
Josh Lee

Probing the epitranscriptome with nanopore sequencing (iCASE)
Alice Seleiro

Uncovering underlying cellular mechanisms at work under high cell density E. coli protein production conditions in biotechnology (iCASE)
Evie Farnham

Evolution, virulence and dispersal of bacterial plant pathogen, Ralstonia solanacearum (iCASE)
Amber Emmett

Machine Learning to Predict Genetic Regulation in Blood Cells
Adam Casey

Improving pest management in coffee plantations (iCASE)
Katie West

Understanding long non-­coding RNA function