Before arriving at Leeds, I studied for my Integrated Masters in Biochemistry at the University of Sheffield. My final year project utilised X-ray crystallography to understand the structure and assembly of pore-forming toxins. During my time at Sheffield, I developed an interest in structural biology which led me to pursue a PhD project that enables further exposure to structural techniques.
Antibiotic resistance undermines effective antibacterial chemotherapy and constitutes a major threat to global public health. A comprehensive response to this problem includes gaining a detailed understanding of the mechanisms by which antibiotic resistance is mediated. My project seeks to characterize the structural and molecular mechanism of several antibiotic resistance proteins found in Staphylococcus aureus; resistance systems that are not currently well understood. In the first instance, I will focus on uncharacterized determinants capable of mediating resistance to the aminoglycosides or mupirocin.