The transport of mRNA from the nucleus to the cytoplasm is an essential step in human gene expression. This project will use a wide range of in vitro biochemical and in vivo molecular cell biology techniques to understand how the dynamic TREX mRNA export complex is assembled in human cells. For recent publications from the labs see Nature Communications (2012) 3:1006 , Science (2011) 324:821-4 , Genes and Development (2010) 24:2043-53 and see https://www.shef.ac.uk/mbb/staff/wilson