Sarah Stevenson (nee Gratton)

Generating distinct actin networks in a single cytoplasm: Structural studies to determine the impact of actin nucleators on filament structure

My project

A fundamental understanding of how a cell responds to its environment, in order to drive changes to cell physiology, is critical if we are to make relevant and appropriate interventions in the context of disease states. Many years of research have demonstrated that the actin cytoskeleton is a focal point of cell regulation, however there are still large gaps in our understanding of mechanisms governing early steps in actin filament formation and how distinct filament organizations can co-exist in a single cytoplasm.