Joe Tyler

Analysis of a Novel Actin Nucleating Machinery regulating Membrane trafficking

Actin nucleation is the key rate limiting step in actin polymerization, and tight regulation of this process is critical to ensure actin filaments form only at specific regions of the cell. We have recently identified a novel, proline dependent actin-binding activity. This project aims to address several fundamental questions to gain insights into the mechanism of proline interaction with actin, and to determine how the interaction can promote filament formation during endocytosis.