Hannah Southam

CO-releasing molecules as novel antimicrobial agents: mechanisms of transport and resistance

CO-releasing molecules (CO-RMs) allow CO to be administered safely and exert potent antibacterial activities distinct from conventional antibiotics. However, we know nothing about how CO-RMs are transported and release CO inside cells. This project aims to determine the pathways for CO-RMs across bacterial membranes by combining molecular genetic and membrane biological approaches. The student will undertake the first aspects in Sheffield and the second in Leeds, but there is much flexibility.