Iliyana Kaneva

Identification of kinase targets in the human fungal pathogen Candida albicans using immunoprecipitation and mass spectroscopy

Candida albicans causes superficial mucosal infections such as vaginitis. In certain groups of vulnerable patients it causes severe, life-threatening bloodstream infections. This project investigates the target of kinases using mass-spectroscopy to identify proteins that are associated with a kinase after it has been immunoprecipitated. Initially the project focuses on the role of kinases during the switch from yeast to hyphal morphologies. Subsequently the scope will be broadened to investigate the role of kinases during the response to stress and biofilm formation.